| title: | Structure and function of genome: reflection of evolutionary and recombination processes; and association with normal and pathological variation |
|---|---|
| reg no: | SF0182721s06 |
| project type: | targeted financing |
| subject: |
1.8. Molecular Biology 1.9. Genetics, Physiology and Microbiology 3.1. Basic Medicine |
| status: | accepted |
| institution: | University of Tartu |
| head of project: | Maris Laan |
| duration: | 01.01.2006 - 31.12.2011 |
| description: | The proposed project is focused on genomic segments and genes responsible for the reproductive (gonadotropins and growth hormone/placental lactogen) and cardiovascular function (blood pressure regulation, embryonic morphogenesis of the heart). The research includes the analysis of the dynamic components of the genome (segmental duplications, functionally interacting genes, sense-antisense transcript pairs) and evolutionarily conserved non-coding regions. Detailed aims and questions: (1) structure, variation, gene conversion activity and evolution, expression and imprinting patterns of LHB/CGB and GH/CSH gene clusters on primate lineage; association of LHB/CGB gene polymorphisms and structural variants with recurrent miscarriage, and GH/CSH variation with intrauterine growth retardation; (2) identification of novel blood pressure regulating genes in Eurasian populations, detection of hypertension-associated polymorphic and haplotypic variants; evolutionarily conserved non-coding genomic segments as gene regulatory elements; role of antisense RNA molecules in regulating genes responsible for hypertension; detection of disease mutations for familiar cases of congenital heart disease in Estonia. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Tarmo Annilo | Tartu University, Faculty of Biology and Geography | Senior scientist | |
| 2. | Ingrid Kalev | Tartu University, Faculty of Biology and Geography | at the moment assistant 0,5/ research fellow 0,5 in Medical Faculty of Tartu University, Department of Human Biology and Genetics; researcher 1,0 in Institute of Molecular and Cell Biology when the application ERIS-762 is satisfied | |
| 3. | Maris Laan | Tartu University, Faculty of Biology and Geography | research professor | |
| 4. | Elin Lõhmussaar | Tartu University, Faculty of Biology and Geography | scientist | |
| 5. | Jaana Männik | Tartu University, Faculty of Biology and Geography | Postdoctoral Research Scientist Senior Scientist | |
| 6. | Gudrun Veldre | Tartu University, Faculty of Biology and Geography | extraordinary senior research fellow | |