| title: | New strategies and methods of asymmetric synthesis |
|---|---|
| reg no: | SF0142725s06 |
| project type: | targeted financing |
| subject: |
1.7. Organic Chemistry and Biochemistry |
| status: | accepted |
| institution: | Tallinn Technical University |
| head of project: | Margus Lopp |
| duration: | 01.01.2006 - 31.12.2011 |
| description: | The main goal of the project is to develop methods of the asymmetric synthesis by designing and elaborating of new chiral inducers (catalysts, including organoctalysts) and applying the new methods in the chemical synthesis of essential bioactive compounds. Within the project the mechanism/chemism of asymmetric transformations will be studied; a method for the synthesis of labeled compounds by asymmetric oxidation will be elaborated; possibilities of the synthesis of different chiral ligands and their complexes with metals (Ti, lantanides etc) and the properties of the complexes will be investigated; the possibilities of the use of new chiral ligands in the asymmetric synthesis will be elucidated; in order to establish the structure/activity relationship of the new compounds (complexes), both, experimental and theoretical calculation will be used; general features of the interactions of substrate-chiral inducer in asymmetric oxidation and its enantioselectivity will be established; a method for the total chemical synthesis of 9,11-secosterols will be elaborated; a method for the synthesis of ribose analogs will be developed; new anti-cancer and anti virus nucleiosides will be developed; a new method for N-monoalkylated (tertiary) or dialkylated (quaternary) amine derivates will be developed; a method for cyclic amines starting from substituted aziridins will be developed; obtained compounds are used as chiral ligands and asymmetric organocatalysts. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Riina Aav | Tallinn University of Technology, Faculty of Science | researcher | |
| 2. | Veiko Allikmaa | Tallinn University of Technology, Faculty of Science | senior reseach scientist | |
| 3. | Tõnis Kanger | Tallinn University of Technology, Faculty of Science | Associate Professor | |
| 4. | Kadri Kriis | Tallinn University of Technology, Faculty of Science | senior researcher | |
| 5. | Margus Lopp | Tallinn University of Technology, Faculty of Science | professor | |
| 6. | Aleksander-Mati Müürisepp | Tallinn University of Technology, Faculty of Science | Senior researcher | |
| 7. | Anne Paju | Tallinn University of Technology, Faculty of Science | Senior researcher | |