| title: | Myogenic regulatory factors and adaptation of locomotory function to the age-dependent and functional changes |
|---|---|
| reg no: | SF0182743s06 |
| project type: | targeted financing |
| subject: |
3.1. Basic Medicine |
| status: | accepted |
| institution: | University of Tartu |
| head of project: | Priit Kaasik |
| duration: | 01.01.2006 - 31.12.2011 |
| description: | Morphological and metabolic modifications in the skeletal muscle can be explained in part by reduced physical activity. In addition, some recent results indicate that functional/structural properties of contractile proteins and in particular the slow MyHC isoform is altered upon ageing leading to a slowdown of the contractile speed. Development, growth, contraction properties and regeneration capability depend on mechanisms regulating the number, type and size of myofibers. Little is known about the role and mechanism of myogenic regulatory factors in adult skeletal muscle. Our previous results show, that exercise has remarkable effect on the synthesis of proteins of contractile apparatus and depends on the character of exercise and type of muscle fibers. Within the current project we rised the question – the extent of the role of myogenic regulatory factors in adult skeletal muscle and how are changes in myogenic regulatory factors related to the adaptive processes taking place in contractile apparatus of skeletal muscle. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Karin Alev | Tartu University, Faculty of Exercise and Sport Sciences | researcher | |
| 2. | Priit Kaasik | Tartu University, Faculty of Exercise and Sport Sciences | docent | |
| 3. | Kalle Karelson | Tartu University, Faculty of Exercise and Sport Sciences | senior researcher | |
| 4. | Luule Medijainen | Tartu University, Faculty of Exercise and Sport Sciences | lecturer | |
| 5. | Ando Pehme | Tartu University, Faculty of Exercise and Sport Sciences | lecturer | |
| 6. | Eve Pihl | Tartu University, Faculty of Exercise and Sport Sciences | senior researcher | |
| 7. | Raivo Puhke | Tartu University, Faculty of Exercise and Sport Sciences | researcher | |
| 8. | Eva-Maria Riso | Tartu University, Faculty of Exercise and Sport Sciences | researcher | |
| 9. | Teet Seene | Tartu University, Faculty of Exercise and Sport Sciences | profesor | |
| 10. | Saima Timpmann | Tartu University, Faculty of Exercise and Sport Sciences | researcher | |
| 11. | Atko-Meeme Viru | Tartu University, Faculty of Exercise and Sport Sciences | Prof emeritus | |
| 12. | Mehis Viru | Tartu University, Faculty of Exercise and Sport Sciences | docent | |
| 13. | Vahur Ööpik | Tartu University, Faculty of Exercise and Sport Sciences | Dean of the Faculty of Exercise and Sport Sciences; Professor of Exercise Physiology | |