| title: | THE ROLE OF ANTISENSE TRANSCRIPTS IN REGULATION OF GENE EXPRESSION |
|---|---|
| reg no: | ETF6597 |
| project type: | Estonian Science Foundation research grant |
| subject: |
1.8. Molecular Biology |
| status: | accepted |
| institution: | TU Faculty of Biology and Geography |
| head of project: | Tarmo Annilo |
| duration: | 01.01.2006 - 31.12.2009 |
| description: | In addition to protein factors that are binding to promoter regions, the expression of a number of protein-coding genes is controlled by different RNA molecules like microRNAs and natural antisense RNAs. The goal of the current project is to elucidate the role of antisense transcripts in expression of blood pressure regulating genes in human. The following specific aims are proposed: 1. Since majority of the antisense transcripts have been described only in silico, we should determine the detailed structure, expression pattern and splicing isoforms of antisense transcripts that are related to blood pressure regulating genes. 2. Test experimentally the functional relationship of overlapping sense-antisense gene pairs. 3. Perform the evolutionary analysis of overlapping gene pairs. How strongly is conserved the location and pattern of overlap? 4. Assess the relationship between the variation of primary sequence and expression of antisense transcripts. Is there a relationship between the specific gene variants, expression level and deviation in blood pressure? |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Tarmo Annilo | Tartu Ülikool | ||
| 2. | Siim Sõber | |||