| title: | Gender peculiarities in parameters characterizing ventricular repolarization spatial and temporal variability in women with various heart diseases |
|---|---|
| reg no: | ETF6842 |
| project type: | Estonian Science Foundation research grant |
| subject: |
3.3. Clinical Medicine |
| status: | accepted |
| institution: | Estonian Institute of Cardiology |
| head of project: | Jüri Kaik |
| duration: | 01.01.2006 - 31.12.2009 |
| description: | This project is the continuation of the research carried out in Estonian Institute of Cardiology during past 9 years evaluating the level of myocardial electrical instability (MEI) by assessment of non-invasive markers of ventricular repolarization prolongation and inhomogeneity (QT interval spatial and temporal dispersion, certain peculiarities in QT segment configuration). The investigations of recent years have demonstrated remarkable gender differences in the ventricular repolarization parameters as well as in their diagnostic and prognostic significance, caused by sex-dependant cardiac ion channel expression determined genetically and modified by the sex hormones. Women are also at 4 times higher risk of developing potentially lethal TdP-type tachycardias during antiarrhythmic drug treatment. The aim of the study is to assess the gender differences of the following non-invasive ventricular repolarization parameters: (1)various modifications of spatial QT dispersion, (2) temporal variability of QTc at 24-hour ECG monitorings, (3) QT interval rate-adaptation, (4) certain QT interval and T-wave configuration peculiarities in various patient populations- in patients of different ages, with and without overt heart disease, during three main phases of physiological menstrual cycle, as well as their prognostic and diagnostic efficacy in MEI assessment in women with various heart diseases. Non-linear signal processing methods using novel, automated QT-analysis algorithms will be applied to 400 digitally stored 24-hour ECG-s from Tallinn Technical University Biomedical Engineering Centre database, as well as Holter recordings of 200 men and 300 women undergoing medical examination in Estonian Institute of Cardiology will be studied. The projects results in elaboration of gender-dependent diagnostic complex of ventricular repolarization parameters for MEI level identification, prediction of efficacy and arrhythmogenic effect of antiarrhythmic drugs in order to optimize antiarrhythmic therapy. |
| project group | ||||
|---|---|---|---|---|
| no | name | institution | position | |
| 1. | Gundega Goldsteine | |||
| 2. | Jüri Kaik | Eesti Kardioloogia Instituut | ||
| 3. | Eleonora Solodkaja | |||